General objective :
Adapting CAD software to Guinea’s epidemiological and operational context to strengthen tuberculosis screening.
Specific objectives :
- Determine the CAD software anomaly score threshold that maximizes the sensitivity or specificity of tuberculosis screening in Guinea.
- Compare CAD software with human reading of chest X-rays and reference tests (GeneXpert, clinicians…) for tuberculosis diagnosis.
- Analyze the feasibility, acceptability and challenges of implementing CAD software in the Guinean healthcare system.
- Estimate the cost-effectiveness of tuberculosis screening using CAD software versus conventional methods.
Method :
A mixed-method study is being conducted.
A cross-sectional study is currently underway to calibrate the DAC (for analysis of pulmonary X-ray images), using gold-standard bacteriological tests such as GeneXpert (and clinical evaluation by TB experts) in Conakry TB clinics.
The study involved patients aged 15 and over with respiratory symptoms who could undergo X-ray and bacteriological examinations.
An analysis of acceptability and feasibility will then be carried out. This will be followed by a cost-effectiveness analysis.
Progress :
Data collection is ongoing.